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KMID : 0880220070450010006
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Journal of Microbiology
2007 Volume.45 No. 1 p.6 ~ p.10
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Production and Biological Activity of Laidlomycin, Anti-MRSA/VRE Antibiotic from Streptomyces sp. CS684
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Yoo Jin-Cheol
Kim Jun-Ho
Ha Jung-Wan
Park Nae-Soo
Sohng Jae-Kyung
Lee June-Woo
Park Seong-Chan
Kim Mi-Sun
Seong Chi-Nam
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Abstract
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Culture broth of a streptomycete isolate, Streptomyces sp. CS684 showed antibacterial activity on methicilin resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE). Among purified substances from the organism, CSU-1, which is active against MRSA and VRE, is a C37H62O12Na (M+, 721.3875), and identified as laidlomycin. The anti-MRSA and anti-VRE activity of CSU-1 was stronger than oxacillin and vancomycin. Phylogenetic analysis showed that strain CS684 is very similar to Streptomyces ardus NRRL 2817T, whereas the ability of Streptomyces sp. CS684 to produce laidlomycin was shown to be unique.
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KEYWORD
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Anti-MRSA, Anti-VRE, polyether antibiotic, laidlomycin, Streptomyces sp. CS684
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